Sentence examples for based on predicted binding from inspiring English sources

This work has utilised a structure-based lead generation approach consisting of homology modelling of the target protein, construction of a library of compounds, followed by modification of hits obtained based on predicted binding mode.

We can also predict CRMs based on predicted binding sites using the PWMs.

250K compounds were ranked based on predicted binding affinity and drug-like qualities and the top 30 were selected for testing against genotype 1b p7 in vitro.

However, based on predicted binding sites of E2F1 in let-7c promoter, we suspected that reduced CDK4 mediated the elevation of let-7c through suppression of E2F1 cell cycle signaling.

As detailed in Materials and methods, we generated distance trees, based on predicted binding scores for 10,000 random peptides using the NetMHCpan [ 41] and NetMHCIIpan [ 42] software, for the DILI-associated alleles and the most common HLA class I and class II alleles in Caucasian populations.

We synthesised citrullinated or unmodified peptide antigens from the fibrinogen, vimentin, collagen type II and aggrecan protein sequences that had been identified - either based on predicted binding capacity to RA-associated DR molecules in a molecular model positioning citrulline at P4, or through previous studies in HLA-DR4-IE-transgenic mice (Table 2) [ 6, 15, 17].

Even though these differences are based purely on predicted binding affinities, the findings correspond to what has been observed for MHC class I binding, where evidence is merging suggesting that MHC class I molecules present peptide on the cell surface at different binding thresholds [14], [15].

First, based on predicted autoregulatory binding sites we count the number of autoregulatory loops.

Before reporting and discussing evolutionary hypotheses based on predicted transcription factor binding sites, we would like to show that these predictions are not random, despite the high rate of incorrect predictions.

For these reasons, a number of studies have focused on identifying combinatorial regulation solely based on predicted transcription factor binding sites (TFBSs).

T cell-dependent development of anti-Factor VIII (FVIII) antibodies that neutralize FVIII activity is a major obstacle to replacement therapy in hemophilia A. To create a less immunogenic therapeutic protein, recombinant FVIII can be modified to reduce HLA binding of epitopes based on predicted anchoring residues.