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It was selected for further pharmacological characterization based on potent inhibition of Raf-1 and its favourable kinase selectivity profile.
Conversely, designing probes based on potent ATP-competitive inhibitors such as probe 2 will minimize nonspecific binding, but these probes will not bind to the full kinome.
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Mr. Stern inquired after the response, and his nephew explained that he'd reached his assumption based on a potent whiff of cologne.
Based on such potent data, GSK says it will be able to seek approval for the MLD treatment in 2017, even though so few children have ever received it.
In an earlier report we described a P2Y14R fluorescent probe, MRS4174, based on the potent and selective antagonist PPTN, a naphthoic acid derivative.
Based on its potent biochemical and anti-proliferative activity, the novel BRD4 inhibitor compound 5i, is a promising lead compound for further investigation.
Our ligand design was based on a potent reduced amide isostere 1, wherein the P2 amide moiety was replaced with an anti-1,2,3-triazole unit.
A 30-membered library of amides based on the potent urotensin II (UII) receptor agonist FL104, has been synthesized from ten different carboxylic acids and three amines.
Their primary function in plants is thought to be as defense agents, based on their potent insecticidal activity, but they also have a range of other biological activities, including anti-HIV, antimicrobial and cytotoxic activities.
Based on its potent antimicrobial activity, rapid killing, and inhibition of S. mutans biofilm formation, ZXR-2 represents a potential therapeutic for the prevention and treatment of dental caries.
Based on the potent anticancer activity of the D-arabino-configured cytosine nucleoside ara-C, novel 2′-substituted-4′-selenoarabinofuranosyl pyrimidines 3a 3u, comprising azido, fluoro, and hydroxyl substituents at C-2′ were designed, synthesized, and evaluated for anticancer activity.
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