Sentence examples for based on potency and from inspiring English sources

This has led to the common practice of selecting compounds based on potency and relative selectivity in blocking hERG potassium currents.

Based on potency and selectivity, mode of compound action and compound availability, 35 compounds, including compounds with novel mechanisms of action and some compounds in clinical use or trials for cancer, were selected for further study.

Similarly, the characterization of compounds based on potency and multiparametric phenotypic analysis adds valuable information to the selection of lead compounds for the purposes of being used as chemical probes to dissect the mechanisms driving the cell cycle, as anti-cancer agents, or both and should be considered an integral part of cell-based chemical screening campaigns.

Of the 14 unique structural analogs evaluated (Supplementary Figure S1), FV-162 was the lead compound based on potency in proteasome inhibition and cell viability assays (Supplementary Figure S2).

These medications are divided into seven classes based on potency as determined by vasoconstrictor assays, with I being the strongest, and VII the weakest.

The shelf life of the rHA formulation with STG citrate, based on potency as determined by SRID, was extended as much as 20-fold, compared to a control formulation without STG citrate.

Dose 2 was also planned to be administered under the same blind, but the protocol was amended so that 19 subjects received dose 2 after they were unblinded (see section "Study design amendment based on potency testing").

Using an experimentally inspired stochastic model, based on the potency and chromosomal distribution of oncogenes and tumor suppressor genes, we show that cancer cells have evolved to exist within a narrow range of chromosome missegregation rates that optimizes phenotypic heterogeneity and clonal survival.

The CMP and LT processes were the most effective and least toxic bioremediation procedures based on mutagenic potency and chemical analysis.

As AZD9773 is differentiated from other anti-TNFα agents based on neutralizing potency and pharmacokinetic attributes, we studied both the safety and efficacy of this product in mouse CLP models.

5,6-Dimethylxanthenone-4-acetic acid, with a methyl substituent on both the 5- and 6-position, was selected as a clinical candidate from all the xanthenone and flavone derivatives synthesised at the Auckland Cancer Society Research Centre, based on its potency and activity against solid murine cancers that are resistant to conventional chemotherapies (Rewcastle et al, 1991).