Samples can be enriched for selected subcellular fractions or for specific type of proteins (based on post-translational modifications).
The signaling pathways of these identified phosphoproteins were mapped using the Pathway Studio program based on post-translational modifications (mainly phosphorylation) (http://www.ariadnegenomics.com/products/pathway-studio/).
Inducible transgene expression was based on post-translational regulation mediated by fusion to an FKBP (FK506 binding protein -based domain targeting the protein -basedidomaineosomal degradatargeting
As this minimal circuit is based on a single transcriptional unit, it provides a new mechanism based on post-translational interactions to generate targeted spatio-temporal behavior.
Alternatively, the inner kinetochore proteins may contribute to an organization of the centromere kinetochore interface that promotes the recruitment of the outer kinetochore proteins, for instance by mechanisms based on post-translational modification.
The present study introduces the first mathematical model of bistable regulation of curli fibers in E. coli based on post-translational interactions of multiple DGC and PDE proteins with the signalling molecule c-di-GMP as the central player.
A previous study suggested that the IFN-α antitumor activity could still involve unexplored mechanisms based on post-translational and translational control of the expression of proteins that regulate cell proliferation and apoptosis.
Similarly, other networks based on the post-translational modifications (nodes: 216, edges: 372), secreted proteins (nodes: 135, edges: 346) and kinases (nodes: 7, edges: 4) were built.
Meanwhile, we categorize regulatory mechanisms into different types based on transcriptional, post-transcriptional, translational and post-translational regulations.
Considering possible mechanisms of synergy between a rocaglate and IFNγ, we envision several scenarios based on rocaglate-mediated translational inhibition.
