Sentence examples for based on positive selection from inspiring English sources

One recent study that used negative selection suggested that it had little effect on gene transcription, though they did not compare their selection protocol to one based on positive selection [ 18].

A stringent fourfold selection protocol based on positive selection via blasticidin, puromycin and EGFP fluorescence as well as negative selection by means of ganciclovir/HSV-TK in selection cell lines was applied and enabled us to enrich for cell lines expressing potent inhibitory shRNAs (Fig. 2).

Hence, an interpretation based on positive selection could be that the follow-up neofunctionalization may impose stronger functional constraints on these ancient duplication genes.

Given the ubiquity of introns in eukaryotes, the dearth of hypotheses based on positive selection is striking, and therefore any such hypothesis is important and at the very least thought-provoking.

This knowledge has made it possible to implement eradication programmes throughout Europe based on positive selection of the most resistant allele (ARR) and negative selection of the most susceptible one (VRQ) [ 2, 3].

While current therapy is based on positive selection with HCV genotype or negative selection with IL28B SNP, and is limited to only some cases, our methods are applicable to all patients [ 13, 18].

We considered selective reporting of interactions based on positive results and selection bias related to availability of genotyping (Supplementary Data).

In women, potential effectiveness of hormonal therapy is dependent upon the patient selection based on positive receptor status [ 57].

The FET and KS test for two different aspects of enrichment - enrichment of genes under positive selection and enrichment among high-ranking genes based on a positive selection score.

It is based on a positive selection likelihood score, termed 2Δ ℓ (see Materials and Methods), that is proportional to the likelihood of positive selection.

We used FET to estimate the enrichment of GO terms in the subset of genes identified as being under positive selection and the KS test to test for the enrichment of the GO terms among the high-scoring genes in the gene ranking based on a positive selection score.