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It should be noted that the XPEHH method described above is also a method that is based on population differentiation.
This possibility is illustrated by the extremely low overlap of identified outlier regions in our sliding-window analyses to detect selective sweeps based on population differentiation.
In addition, we performed sliding-window analyses for each dataset to detect selective sweeps in the genome based on population differentiation using custom R-scripts.
For instance, Namroud et al. (2008) reported 3.7% of the SNPs to be potential candidates for selection among natural populations of white spruce using a summary-statistic outlier-detection method based on population differentiation.
To evaluate the impact of the SNP dataset differences on genome-wide scans for signatures of natural selection, we performed (iii) sliding-window analyses (100 kb windows, 25 kb step size) to identify signals of putative selective sweeps based on population differentiation.
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(The grants were prorated based on population).
Neutrality tests for microsatellites focus mainly on unlinked loci and are based on either population differentiation (FST) or reduced variability (lnRθ).
Most have been based on extreme population differentiation [ 1- 3], the enrichment of rare mutations in the site frequency spectrum [ 4, 5], or patterns of extended haplotype homozygosity [ 6- 8] (See [ 9, 10] for further review).
The d i statistic is a new population-genomics strategy based on levels of population differentiation, which determines robustly whether selection acts on newly arisen or pre-existing variations [ 10].
The methods employed include: 1) Tests designed to identify deviations of the Site Frequency Spectrum (SFS) from neutral expectations (Tajima's D, Fay and Wu's H and Fu and Li's D* and Fu's F*), 2) Tests focused on the identification of high-frequency haplotypes with extended Linkage Disequilibrium (LD) (iHS and Rsb) and 3) Tests based on genetic differentiation between populations (LSBL).
Altogether, this resulted in increased proteoglycan deposition by the entire cell population [ 46], based on the differentiation of MSCs toward NPC-like cells and their trophic effect on the resident cell population.
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based on serologic differentiation
based on population size
based on population structure
based on population balance
based on immunophenotype differentiation
based on tissue differentiation
based on population density
based on population coverage
based on population growth
based on population housing
based on population balancing
based on syndrome differentiation
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