Sentence examples for based on plasma concentration from inspiring English sources
In PBLs, systemicREPs based on plasma concentrations also deviated from intakeREPs, in a manner similar to that of systemicREPs of hepatic end points based on plasma concentration.
☑ Current TB treatments and dosing regimens are based on plasma concentration with less consideration paid to local distribution of administered compounds within the lung.
Because of the very small margin between a safe and lethal dose, NTIDs must be dosed carefully based on plasma concentration, and patients should be monitored closely for any signs of drug toxicity.
Pharmacokinetic parameters determined based on plasma concentration vs time data were maximum plasma concentration (Cmax), elimination half-life (t1/2), area under the plasma concentration vs time curve (AUC) from time 0 to infinity (AUC0-∞), volume of distribution at steady-state (Vss) and plasma clearance (CLp) (Rowland and Tozer, 1995).
Based on plasma concentrations, two exposed subgroups were defined.
Creatinine clearance rate (CCR; L/min) and renal urea reabsorption ratio were estimated based on plasma concentrations of urea and creatinine, and total excretion of urea and creatinine in urine.
Using the data obtained from a bioequivalence investigation of potassium aspartate (test vs reference formulation), the authors demonstrate the inconsistency of bioequivalence based on plasma concentrations and standard methods.
In Wistar rats, the pharmacokinetic parameters of TW01003 and TW01003 sulfate after i.v. administration of TW01003 were derived from noncompartmental model, based on plasma concentration-time profile.
The systemicREPs based on plasma concentrations for Cyp1a1 and 1b1 gene expression in PBLs and liver show similar deviations from intakeREPs for all DLCs tested.
In the SAD study, the AUC from 0 to the last quantifiable data point (AUClast) was calculated by the trapezoidal rule, based on plasma concentrations of luseogliflozin.
Based on the intake dose and hepatic concentrations, deviations from the half log unit uncertainty are observed for 4-PeCDF, but systemicREPs based on plasma concentrations are close to the WHO-TEF of 0.3.
