Sentence examples for based on pivotal from inspiring English sources

Exact confidence intervals for a proportion of total variance, based on pivotal quantities, only exist for mixed linear models having two variance components.

Decisions concerning drug safety and efficacy are generally based on pivotal evidence provided by clinical trials.

Based on pivotal phase III randomized controlled trials (RCTs) showing survival benefit, ipilimumab was approved by the US Food and Drug Administration FDAA) for metastatic melanoma [ 5, 6].

DOI: http://dx.doi.org/10.7554/eLife.02869.011 Based on pivotal NGS studies, two different evolutionary models have been proposed in CLL, namely gradual linear and branching evolution (Knight et al., 2012; Schuh et al., 2012).

Generalized confidence intervals (GCIs) introduced by Weerahandi [1993. Generalized confidence intervals (Corr: 94V89 p726). J. Am. Statist. Assoc. 88, 899 905] are based on generalized pivotal quantities (GPQs) and can be constructed for a much wider range of models.

Based on the pivotal role of the liver in metabolizing xenobiotics, the experiments are focused on hepatocytes.

Post-hoc analyses based on the pivotal trials do not suggest a differential response in women or men as another possible explanation [24].

Much of the Pickens Plan was based on a pivotal study released in May by an ad-hoc group of energy authorities including the U.S. Department of Energy, the American Wind Energy Association (AWEA and American Electric Powerr].

Based on its pivotal role during tumoral angiogenesis, a contribution of PAI-1 in lymphangiogenesis is anticipated, but not documented.

The proline epimerase, PrpA, was described as a B-cell polyclonal activator and inducer of IL-10 [22], suggesting that immunity to this protein may promote clearance in our model based on the pivotal role IL-10 plays in Brucella pathogenesis [30], [34].

Based on its pivotal role in the bone remodeling process, RANKL has become a therapeutic target.