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Pill count-based medium-term adherence: Average percentage of days patients took ARVs as expected based on pill counts as noted in clinic or pharmacy records.
Our results demonstrate the clear need for standardisation in reporting of adherence data that are based on pill counts.
Adherence monitoring was conducted at each follow-up visit and was based on pill counts and self-reports from caregivers.
Patients' compliance during study treatment, based on pill counts, was ≥ 83% and was comparable in the three treatment groups.
The mean compliance based on pill counts and diary reports were compared between the two study arms by paired Student's t test or signed rank test, as appropriate.
In both trials, we found that adherence based on self-report of number of missed doses was higher than that based on pill counts.
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Based on pill count, the percentage of prescribed doses taken averaged 94 ± 0.4% in the DHEA and 96±0.4%4% in the placebo group.
The compliance rates, which were based on pill count, were 95.6 ± 4.8% and 95.4 ± 5.1% in the placebo and FRG groups, respectively.
Based on pill count, mean compliance rates with treatment were 97.2% in the etifoxine group (n = 98) and 98.5% in the alprazolam group (n = 98).
Although the primary outcome analysis will be by randomization group (intention to treat, discussed previously), we will also assess variability of response to vitamin D supplementation (on-treatment analyses), where treatment is defined by adherence based on pill count or achieved 25OHD concentration.
Based on Pilling et al. [2].
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based on census counts
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