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Based on physicochemical technologies, different methods have been developed to degrade lignin and destroy the crystal structure of cellulose in ligno-cellulosic substrates, such as microwave, ionizing radiation, steam explosion, acid or alkali dilution, and oxidation or a variety of their combinations [ 5].
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Finally, it will be interesting to combine the MCS-based similarity measure and the hybrid vectorization method with similarity measures based on physicochemical property descriptors.
Can we control assembly and disassembly using modulators based on physicochemical principles?
based on physicochemical and 3D similarity studies.
Briefly, the structure-based druggability assessment identifies all cavities on a given three-dimensional structure and assesses their likely druggability based on physicochemical parameters that are independent of the homology of the protein to known drug targets.
Results show that our kinase scoring function, based on physicochemical descriptors, successfully generates kinase-focused libraries.
In these plots, diversity based on physicochemical properties is represented by the intra-set Euclidean distance of the six physicochemical properties i.e., values in Table 4.
Surprisingly, all descriptor sets based on physicochemical properties are grouped and score negative on the first principal component.
Z-scales are based on physicochemical properties of the AAs including NMR data and thin-layer chromatography (TLC) data.
Proteochemometric modeling [1] adds a target description, based on physicochemical properties of the binding site, to these models.
For example, models that predict pharmacokinetic behaviour (absorption, distribution) of compounds based on physicochemical properties could be combined with predictions of liver transport based on QSAR transporter models.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com