Sentence examples for based on phenotypic changes from inspiring English sources
Again this is highly relevant for screening where the biological end point is based on phenotypic changes rather than on binding to a specific target.
Consequently, mutation rate has been conventionally estimated indirectly based on phenotypic changes, such as variation in antibiotic resistance.
Six stages were selected for these analyses based on phenotypic changes that were observed during MS formation.
The metabolic profiles of tumour cells are dramatically different from normal adult cells as their metabolic requirements shift based on phenotypic changes, including increased proliferation and survival in the acidic- and nutrient-depleted tumour microenvironment.
Recent examples include characterization of genes involved in cell division by analysing time-lapse image sequences of human cells (Neumann et al., 2006), estimation of drug effects based on phenotypic changes measured in human HeLa cells (Loo et al., 2007) and identification of genes involved in cell morphology in Drosophila using RNA interference (RNAi) (Kiger et al., 2003).
This complex genotype-phenotype mapping presents a challenge to inferring genetic evolution based solely on phenotypic changes.
Although our analyses were based on phenotypic evolution, these phenotypic changes are likely to be a result of a series of multiple genetic changes fixed by natural selection and neutral drift accumulated over long time periods.
We also sought to determine the gender difference in liver function changes, based on phenotypic and genetic susceptibility to MetS and T2DM.
It will be exciting to see the molecular revolution unfold, particularly for wild stocks, within the field of fisheries-induced evolution, and especially how molecular evidence may support or change the conclusions that have been based on phenotypic data.
It is based on phenotypic equations for individual micro-organisms.
The bacterial isolate was identified based on phenotypic, biochemical, and molecular means.
