Sentence examples for based on phenotypic analysis from inspiring English sources

In addition, Sro7p plays a positive role in secretion based on phenotypic analysis of loss-of-function mutants as well as genetic studies demonstrating suppression of a broad range of secretory mutations by SRO7 overexpression [19].

Studies on Radiolaria have progressed since the early work by Haeckel [ 1, 2], which was based on phenotypic analysis.

Based on phenotypic analysis by FACS, we therefore isolated CD9+/CD90+/CD166+ OC cells from five patients and analyzed the kinetics of cultivation and the potential for differentiation.

Indeed, mouse Ldb1 has been implicated in Wnt-related processes, based on phenotypic analysis of Ldb1 knock-out embryos and tissues (Mukhopadhyay et al., 2003; Mylona et al., 2013).

We use a novel strategy based on phenotypic analysis of paralogs and predict that, in Caenorhabditis elegans, off-target effects occur when an mRNA sequence shares more than 95% identity over 40 nucleotides with the dsRNA.

Based on phenotypic analysis we find that glp-4 (bn2 ts ) is partially deficient for valine-tRNA synthetase function in the soma at the restrictive temperature, thus raising the question whether changes in organismal properties in glp-4 (bn2 ts ) mutants are due to germ cell deficiency or reduced protein synthesis.

The model he eventually proposed was based on phenotypic and cytological analysis of flies containing varying numbers of X chromosomes and sets of autosomes (Bridges 1921, 1925).

Based on phenotypic and genotypic analysis of 951 pedigreed baboons, we identified three half-sib-pairs with contrasting phenotypes for LDL-C as described [ 91].

Based on phenotypic and functional analysis as well as dependency on several transcription factors, the authors conclude that at least 4 lineages of NK cells can be defined: conventional NK cells that circulate in the blood (cNK), thymic NK cells, and two types of trNK cells (liver/skin versus uterus).

Second, in cases where the diagnosis of CFNS is strongly suspected based on phenotypic assessment, very careful analysis both for variant point mutations and alterations in EFNB1 copy number (both decreased and increased) may be required to achieve a definitive diagnosis.

Fourteen preliminary hit compounds were selected for further analysis, based on phenotypic robustness as well as the combination of phenotype and whether or not the docked location predicted interaction with EGF.