Sentence examples for based on pharmacokinetic data from inspiring English sources
Initial plasma concentrations of inhibitors (study drugs) were calculated based on pharmacokinetic data.
Based on pharmacokinetic data, OD, two times daily (BID), and three times daily schedules were evaluated.
The sample size was based on pharmacokinetic data from a previously published study (28).
The recommended phase II dose of telatinib is 900 mg BID as continuous dosing based on pharmacokinetic data, the toxicity profile and the biomarker evaluations.
Based on pharmacokinetic data, paliperidone 6-12 mg/dandand risperidone 2-4 mg/day were compared because they were expected to provide similar systemic drug exposure [ 2].
The choice of these concentrations is based on pharmacokinetic data of a phase 3 randomised study following 3- and 24-h infusions of paclitaxel at dose levels of 135 and 175 mg m−2.
Antibiotic dosage regimens used in ICU patients are often based on pharmacokinetic (PK) data that were obtained in healthy volunteers or less severely ill patients.
Based on pharmacokinetic modelling data demonstrating high drug binding to human plasma proteins, an optimised dosing schedule of 30-min i.v. bolus (IVB) followed by 4-h CIVI has been pursued.
In response to increasing vancomycin MICs in MRSA isolates, the Infectious Diseases Society of America, the American of Society of Health-Systems Phandacisthe and the Society of Infectious Diseases Pharmacists developed weight-based dosing recommendations for vancomycin based on pharmacokinetic and pharmacodynamic data (15 20 mg/kg/dose IV administered every eight to 12 hours) [ 7].
This is based on pharmacokinetic and pharmacodynamic data showing that even when denosumab is given only every 12 weeks, it leads to maintenance of adequate serum concentrations of the drug as well as persistent suppression of markers of bone turnover during the longer dosing interval.
The design was based on pharmacokinetic and pharmacodynamic modelling of existing data for both insulins.
