These initiatives propose use of in vitro cellular systems based on perturbations of toxicity pathways.
The two gene expression datasets (A and B) are based on perturbations of essential versus non-essential genes.
GSA is based on perturbations of the entire parameter space, where input factors are examined both individually and in combination (Ligmann-Zielinska, 2013).
An equation of state based on perturbation theory, the simplified perturbed-chain statistical associating fluid theory (PC-SAFT) is applied to binary systems that include an extensive number of non-associating compounds.
This method is based on perturbation analysis and the change-of-variable technique.
The approaches aimed at nonlinear systems are mainly based on perturbation theory, where the effect of the quantization of each algorithm's signal on the quality of the output signal is supposed to be small.
Based on perturbation arguments, this local nature of the optimal trajectory is then used to provide an approximation of the optimal trajectory for the full problem in dimension six, and finally simple approximation methods are developed to solve the problem.
This way, we depart from earlier BEM derivations based on perturbations, which imply the presence of 'small' amounts of randomness in the elastic continuum, and move towards the development of methods that are computationally efficient alternatives to Monte Carlo simulations.
Instead of trying to measure each reaction's detailed kinetics, which faces huge technical challenges [ 8, 13], we undertook a macroscopic view of developing a computational model based on perturbation-response approach and the law of information conservation.
Much of the literature on clathrin-independent endocytosis is based on perturbations with differential effects on the uptake of transferrin and putative clathrin-independent cargoes (Puri et al., 2001; Sabharanjak et al., 2002; Sandvig et al., 2008; Doherty and McMahon, 2009; Hansen and Nichols, 2009; Lakshminarayan et al., 2014).
