Sentence examples for based on perfect seed from inspiring English sources
To investigate the impact of convergent evolution on miRNAs in our setting, we selected the most conserved arm of each miRNA as previously explained and classified these into 374 distinct groups based on perfect seed sequence identity (fig. 2 C).
Erk1/2 are not predicted targets for these miRNAs based on perfect base pairing of the seed region, however, increasing evidence suggests that nucleotides other than the seed region contribute to efficient miRNA targeting.
Consider the corresponding subplots of Figs. 12 and 13: despite using fewer seeds, (text {OAS}_{text {mg}}) performance is strong (and competitive with seeding based on perfect link information) across wide initial ranges of (p_{text {neg}}) values.
Even quite-noisy link information about (G) allows the modified greedy planner to consistently perform extremely well.4 As thresholds increase, it appears that precise link information is less and less important in remaining competitive with seeding based on perfect link information.
Using the identified seed sequences, we sought targets for the tRFs in the D. melanogaster genome based on perfect matches to 3'UTRs.
In general, this algorithm performs target predictions based on perfect and conserved matches between the genes untranslated region (UTR) and the first six nucleotides of the seed sequence.
miRNAs bind their target sites based on perfect or near-perfect sequence complementarity.
This study is performed partially based on PERFECT D Trial (Current Controlled Trials No.ISRCTN57478950).
In both cases, miRNAs direct RISC to recognise their target mRNAs based on perfect or nearly perfect antisense complementarity between the miRNAs and the mRNAs.
Indeed, our results based on the perfect complementarity between seed sequence and targets are consistent with the experimental study in D. melanogaster (Tyler et al. 2008).
Second, the target sites predicted in this study were detected only based on the perfect complementarity to the seed sequences as mentioned above, and it is necessary to confirm the functionality of these target sites experimentally.
