Sentence examples for based on perfect complementarity from inspiring English sources

Moreover, in most animals, regulatory RNAs such as miRNAs have incomplete homology with their target sequences [ 31] and, therefore, our predictions based on perfect complementarity may have missed some potential targets in the host genomes, again leading to false negative results.

Currently, the most efficient tool available for this purpose is the bioinformatics approach, which is based on perfect or near perfectly complementarity between miRNAs and their targets.

miRNAs bind their target sites based on perfect or near-perfect sequence complementarity.

In both cases, miRNAs direct RISC to recognise their target mRNAs based on perfect or nearly perfect antisense complementarity between the miRNAs and the mRNAs.

Indeed, our results based on the perfect complementarity between seed sequence and targets are consistent with the experimental study in D. melanogaster (Tyler et al. 2008).

Second, the target sites predicted in this study were detected only based on the perfect complementarity to the seed sequences as mentioned above, and it is necessary to confirm the functionality of these target sites experimentally.

TargetScan mainly depends on perfect complementarity to the seed region of miRNA and then extends to complementarity outside the region.

Originally, plant miRNA targets have been studied via computational prediction, which is based on either perfect or near -perfect sequence complementarity between miRNA and the target mRNA or sequence conservation among different species [ 10].

Although miRNAs recognize their target genes based on the complementarity to the seed region, our results suggested that miRNAs with the same seed sequences but different duplex structures may have different silencing efficacies according to the Tm2 8 − 0.53 × miTm1 5 values.

Binding affinities are based on structural complementarity between proteins and binding sites, with molecular binding sites modeled by bit-strings.

This reaction is based on nucleotide complementarity [19].