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The familial cases were divided into two groups based on pedigree analysis.
Numbers of definite and probable obligate carriers (based on pedigree analysis) are in addition to tested carriers.
Based on pedigree analysis, 29 affected dogs shared a common ancestor, indicating a strong genetic background for epilepsy in Border Collies.
Table 1 shows the major clinical features for all 29 cases; 19 singleton and 10 familial cases based on pedigree analysis and echocardiography of family members.
The familial patients from both cohorts were further divided into high- and low-risk familial breast cancer based on pedigree analysis.
Previous studies based on pedigree analysis of D-loop regions reported much higher rates compared with phylogenetic studies, which suggests the presence of deleterious mutations (Parsons et al. 1997; Howell et al. 2003; Millar et al. 2008).
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Currently, prediction of risk for complex diseases is based mainly on pedigree analysis but this approach yields predictions of risk that are of low precision; for example predictions would be identical for full siblings without offspring, yet the genetic variation among them accounts for half or more of the genetic variance [3], [4].
Relationships based on pedigree (A) and linkage analysis (G LA ) cover only recent relationships because of the limited depth of the known pedigree.
The 8 accessions used in the analysis were selected as the most diverse materials (based on pedigree, phenotype data and some initial marker analysis) from a pool of breeding lines and germplasm collection available to us.
Accumulation of inbreeding was calculated based on pedigree relationships.
Combining MBV predictions with pedigree based predictions gave 1.05 - 1.34 times higher accuracies compared to predictions based on pedigree alone.
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