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On the other hand, some other methods emerged which were based on pathways of gene sets.
The definition of quality indicators is based on "pathways of coherent decisions" and is superior to the rate-based/criterion-based methodology.
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However, it is not a straightforward task to construct a prognostic signature based on pathways that are composed of overlapping sets of genes.
The increased stability of biomarkers based on pathways has resulted in isolation of significant ovarian and breast cancer pathways which have been independently identified as being cancer-related.
The development of drugs based on pathways inhibitors [ 58] exploiting the connectivity maps of Survivin to multiple signaling circuits [ 4] may result in a more effective approach.
To address the problem that gene expression varies in different diseases and cell types, we searched for a common cell with pleiotropic genes based on pathway analysis of GWAS.
Based on pathway aberration profiles of colon and ovarian cancers, we identified two additional aggressive (p <0.05) subgroups.
Based on pathway enrichment analysis of the DEGs using KEGG, the major public pathway-related database [ 79], genes identified in the tolerant genotype are mainly involved in signal transduction and metabolic pathways.
The second strategy was based on pathway analysis with a combination of network information.
Potential controlling pathways of fatty acids in B. napus were inferred based on the pathways of fatty acid synthesis within Arabidopsis [ 31, 38] and other plants [ 42, 78] and also using gene interaction analysis and QTL epistasis analysis.
The data presented here provide new evidence supporting the continued pursuit of interventions designed to combat age-related disease based on genetic pathways of aging discovered in lower organisms.
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