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This review discusses hypotheses based on pathways specific to a metabolic factor in MetS-associated OA, such as the role of advanced glycation end products (AGEs) and glucose toxicity.
Interestingly, our unbiased scan based on pathways collected in Biocarta also indicated that the overall distribution for all the SNPs within the downstream genes targeted by Gleevec appears to be significantly different from the null distribution.
Due to the fact that, in general, mass spectrometric measurement of low abundance proteins is extremely sparse, we developed a metaprotein analytic approach for the analysis of pathway specific phosphorylation changes, based on pathways from MSigDB.
On the other hand, some other methods emerged which were based on pathways of gene sets.
For this analysis, we constructed a model of diabetic dyslipidemia based on pathways described by Ginsberg (3) (Fig. 1).
The increased stability of biomarkers based on pathways has resulted in isolation of significant ovarian and breast cancer pathways which have been independently identified as being cancer-related.
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Several modeling approaches to the progression and recurrence of cancer have been recently proposed based on pathway-based signatures [10], [11], [12].
This filtering may be achieved either by ranking as has been previously discussed, clustering of results based on pathway similarity or overlap [68], allowing the user to exclude pathways based on the presence or absence of specific intermediates that the user chooses to avoid, or some mixture of all of these.
The second strategy was based on pathway analysis with a combination of network information.
Altogether 3,661 compounds were obtained for rice based on pathway mappings.
This network could reveal potentially novel disease relationships that are solely based on pathway association and cannot be readily identified through literature search.
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