Sentence examples for based on pathway level from inspiring English sources

To find out how these related to pathway aberrations, and to identify new subgroups based on pathway level changes, we hierarchically clustered the samples into small and homogeneous clusters characterized by a unique set of pathway aberrations (Additional File 3, Figure 2, Figures S1-S7 in Additional File 4,).

Some of them classify tumor samples based on pathway-level measurements [ 30]; many of them, such as PWEA [ 31] and GSEA [ 32] identify perturbed pathways between two distinct phenotypes (e.g., tumor vs. normal) using expression data [ 28].

Functional association analysis performed by ToppCluster based on pathway networks showing enriched terms from Gene Ontology and pathways.

A desired application of these results involves eventual clinical uses which will be capable of using off the shelf enrichment algorithms for genes (e.g. GSEA, [ 16]) to automatically infer phenotype differences based on pathway (and other gene set) -level feature vectors.

Based on the pathway level impact analysis result, we suggested that the functional importance of somatic mutations on the 32 genes is bigger than that of the others.

This can provide methods for supplementing or replacing gene-level activation features with additional features which form new biomarkers based directly on pathway-level activations.

Extracted physical data was further classified into AFL participation pathway levels based on the team levels reported in each study.

Loss of tuberin antigen was accompanied by an expected activation of the mTORC1 pathway based on increased levels of phosphorylated (Ser 240/244) S6 (pS6).

First we aimed at identifying active signalling pathways based on the expression level of transcriptional regulators.

Two clusters were roughly identified based on the level of interactions between the pathways.

This story would mark a beginning, not an end, to identify novel pathways of complex cancer based on systems level.