At least in AD, it has been challenging to define the nature of the 'immune-system dysregulation' based on pathway-type analyses; the overlap between the SAPS/SMS and biomarkers of AD suggest that the 'immune-system dysregulation' may, in fact, reflect senescence [ 71]. aB, brain; C, cerebrospinal fluid; P, plasma.
It is encouraging that the biology is reflected in this grouping, since the modules align with functional associations based on pathway and GO term enrichment analyses (Table 3 and Additional file 1).
Finally, functional pathways were annotated based on KEGG pathway analyses.
Based on microarray- and pathway analyses, 6 genes of interest were selected for confirmation by q-PCR.
One possible candidate for a downstream target of HER-2 was the PI3K AKT pathway, based on previous analyses in other tumour types (Knuefermann et al, 2003; Qi et al, 2009); hence, we focused on this pathway.
Because these three mutations affect components of the insulin/IGF-1 signaling (IIS) pathway, no conclusions based on correlation analyses alone will necessarily apply outside that pathway.
Based on a new type of metabolomic analysis, we have presented a method for coarse-grained representation of changes in a metabolic network in developing silkworms (Fig. 5b d), whereas classical SI-labeled metabolic studies are based on targeted analyses of specific metabolic pathways, such as glycolysis or gluconeogenesis.
Growth on different substrates was tested for R. litoralis to substantiate the reconstruction of metabolic pathways based on the genomic analyses.
Recent studies on genetic alterations of thymoma based on (LOH) analyses inferred two different genetic pathways of tumorigenesis of thymoma, and heterogeneous genetic alterations in subtypes of thymoma, were identified by CGH and LOH analyses [ 22, 23].
Based on these analyses, they were challenged to develop care pathways for patients with COPD, heart failure and stroke.
