Sentence examples for based on pathway activation from inspiring English sources

Using a mixture modeling approach, we clustered human breast cancer into ten different groups based on pathway activation profiles.

Our method is better at differentiating prognosis based on individual pathway activation than the approach employed by Bild et al. for a human ovarian cancer dataset.

The heritable labeling in our TBI studies using Gli1-CreER T2 driver mice was designed to fate label based on Shh pathway activation with tamoxifen on Days 2 and 3 to capture the early response to injury.

Protein kinase C (PKC) is a serine/threonine protein kinase family; PKC family members are classified into three major groups based on their activation pathways [ 6]: classical PKC isotypes (α, βI, βII and γ) are activated by diacylglycerol (DAG) and calcium, novel PKC isotypes (δ, ϵ, η and θ) are activated by DAG, and atypical PKC isotypes (ζ and ι/λ) are not regulated by DAG or calcium [ 7].

This provided us with the opportunity to compare a robust predictor of docetaxel sensitivity across the current dataset of 133 patients that were clustered based on their oncogenic pathway activation status.

The senescence program is realized through autocrine/paracrine pathways based on the activation of a peculiar senescence-associated secretory phenotype (SASP).

Resistance to VEGF-directed targeted agents has been simplified into two main mechanisms: one involving the potentiation of the VEGF axis and the other based on the activation of alternative pathways and growth factors (Powles et al, 2011).

First, we define the single-gene based pathway activation metric.

Thus, the mechanisms of resistance to antineoplastic therapies might be due to stem-cell like properties of tumor cells that have undergone EMT, allowing for self-renewing of a proportion of cells within the tumor based on the activation of central signaling pathways that are common to both processes, such as TGF-β, wnt, Notch and Hedgehog [13].

These results suggest that NK-4 is a potential agent for therapy for neurodegenerative disorders based on the activation of survival signaling pathways.

Thus the mechanism of protection by VLPs against AKI is based on activation of both pathways leading to survival.