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Date of diagnosis is based on pathological diagnosis as reported to the WA Cancer Registry.
In the 148 patients with lupus nephritis, 36 patients were diagnosed as co-existing with renal TMA based on pathological diagnosis.
Since these cutoffs were generated from different samples (only partly based on pathological diagnosis), 20, 22– 24 they may not be comparable.
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Although diagnosis is based on pathological findings, an early diagnosis is crucial because of poor prognosis compared to other types of pulmonary hypertension.
Assignment to the Catastrophic Illness classification requires a definitive diagnosis based on pathological findings or clinical evidence that is widely accepted as sufficient to make a diagnosis.
For all cancer patients, information on tumor stage at diagnosis (based on pathological and clinical tumor node metastasis (TNM) classified according to the UICC system [ 8]), type of primary treatment (type of surgery, chemotherapy, hormonal therapy, and radiotherapy), and comorbidity (collected since 1993) is routinely collected.
A definitive diagnosis is based on pathological, histological, and immunohistochemical findings.
The definitive diagnosis is based on pathological assessment after nephrectomy, which shows areas of parenchymal destruction and necrosis, as well as interstitial fibrosis and chronic inflammatory infiltrate composed of plasma cells, lymphocytes and numerous lipid-laden macrophages.
According to the latest WHO classification, diagnosis is based on pathological examination 2; therefore, cytodiagnosis by aspiration biopsy would be insufficient.
However, final diagnosis should be based on pathological detection.
SCTAT diagnosis is usually based on pathological examination of the tumor and typical clinical presentations are usually consistent with a hormone-secreting tumor, resulting in precocious puberty in children or menstrual disturbances, such as amenorrhea, in reproductive age women.
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