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We constructed two Markov models to estimate the extent of overdiagnosis: one to estimate screening parameters based on the Age trial data (parameter estimation model), and one to estimate overdiagnosis based on parameter estimates from the first model (overdiagnosis model).
In real situations, where actions must be based on parameter estimates made from incomplete or limited information, the practice of iterative refinement of estimates and policies is likely to result in significantly improved outcome.
The rearranged VBGF gives an estimate of average age-at-length based on parameter estimates.
Correlation analyses were based on parameter estimates extracted from the most significantly activated voxel in the VLPFC.
The model will be a Markov model and the transition probabilities will be based on parameter estimates derived from the trial (and other sources from within the literature).
In particular, as we show in Supplementary Note 1 in Additional file 1, based on parameter estimates for optical mapping data, restricting alignments to eight missing cuts or five false cuts, consecutively, should retain high sensitivity.
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Predictions in the validation process were made based on parameters estimated from estimation sample.
3) Among simulations based on parameters estimated from single limitation, the minimum model best described the experimental observations.
Based on parameters estimated via PK-PD-TD correlation, the model successfully predicted the tumor growth kinetics and hepatoprotection at different dose regimes.
In the current study, we simulated datasets based on parameters estimated for five of these genes, but enforcing a molecular clock.
Using these models, the genome-wide characteristics, such as total number of genes and exons, can be roughly predicted based on parameters estimated from available limited genomic data, e.g. exon length and exon/gene ratio.
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