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As expected, proteins with similar domain organizations tend to be clustered together based on overall sequence homology.
Typically, the identity of genomically sampled organisms was determined based on overall sequence similarity to previously known genomes.
As a consequence, orthology of vertebrate ENC genes to their counterparts in invertebrates might be no longer traceable with conventional phylogenetic methods based on overall sequence similarity.
Despite the distant relationship TBLASTN searches of the reference human mRNA database with the different 8q24.3 ZNF protein sequences indicated that another member of the 8q24.3 locus was in general the closest relative based on overall sequence similarity.
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In this study, I used a GO annotation procedure based mainly on overall sequence similarity using BLAST searches [ 81].
The application of HMMs to plant genomes enabled us to identify 49 families that encompass all Angiosperms ('higher plants') SDRs, each family being sufficiently conserved to enable simpler analyses based only on overall sequence similarity.
The identification is based on overall amino acid sequence and overall structural homology with human cortactin.
Based on overall domain structures and HMG box sequences, the Acropora Sox genes considered here clearly fall into four of the five major Sox classes.
We hypothesize that MRI could represent a novel class of genomic signals, based on overall composition and clustering of nucleotides rather than particular sequence motifs.
MultiLoc2 uses several subpredictors based on overall amino acid composition, identification of sorting signals, and detection of sequence motifs.
Earlier we had reported an initial phylogenetic grouping of 163 predicted P450 sequences (including even partial fragments) into 26 clusters based on overall general homology criterion [ 15].
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