Based on our scoring function (see Methods) we provide a ranked list of potential PPI drug targets (Table 2).
Prediction of gene functions based on our set of function-specific short motifs can also provide a very useful alternative to homology-based annotation methods, especially that a huge number of trypanosomatid genes are not conserved in other organisms.
With τ = O ( r ), the best complexity of the primal-dual interior-point method for a linear optimization problem based on our new proximity function with p = log r and q = 1 is given by O ( r log r log r ϵ ).
Nevertheless, based on our findings, a function of Drep-2 in regulating mGluR-mediated local translation is a possible scenario, which is now open for further investigation.
We agree that the selection of non-moonlighting proteins is based on our current knowledge of function of the proteins and it is possible that secondary function may be found for the proteins in the future.
And it is based on our bodies as the function in the everyday world, using thought that arises from embodied metaphors.
The neurogenic bHLH (basic helix loop helix) transcription factor NeuroD6 is an excellent candidate to assume such a dual function, based on our previous findings showing its role as a co-regulator of mitochondrial mass, cytoskeletal remodelling, anti-apoptotic and molecular chaperone networks (Uittenbogaard and Chiaramello, 2002, 2005; Baxter et al., 2009; Uittenbogaard et al., 2009, 2010).
In this study, we evaluated the effect of LY30 with respect to Hsp27 survival functions based on our previous work hinting at a pleiotropic role of this small molecule.
We also present an algorithm that implements a choice function based on our formalization.
The utility function based on our analytical approximation of PER is introduced in Section 3. The interference model is later used in the proposed MAC algorithm, that is derived in Section 4. The proposed algorithm is analyzed and evaluated through computer simulation in Section 5, and we conclude the paper in Section 6.
