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Based on our computational results, one may speculate that neurological dysfunctions in gyrate atrophy and ornithine translocase-deficient patients may be caused by reduced GABA synthesis in the small intestine.
Based on our computational results, we hypothesized that introducing a hydroxyl group to the inhibitor could improve its potency.
Fifth, our work was carried out based on our computational strategies, which required further experimental validation.
In general, there is a very good correlation between the experimental data with the predictions based on our computational algorithm.
Based on our computational tool, a total of 46 potential targets were identified for the 19 sugarcane miRNAs.
Based on our computational prediction, total LV mass underwent a 12.8% increase from 7.5 to 30 months.
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Based on our theoretical and computational results we argue that a clever definition of the recursion, allowing for strong dominance criteria, is crucial in the design of a multiobjective dynamic programming algorithm.
In summary, this study based on our theoretical and computational models characterizes the behavior of the intrinsic apoptosis pathway under complex stochastic perturbations, and suggests that certain deterministic features, such as system bistability and IAP as potential therapy target, still remain in the presence of noise.
The finite element code and biophysical contraction model are based on our previous work in computational methods and mouse modeling (11, 13).
Based on our experimental results and computational modelling, we propose a displacement model of INM, in which, after mitosis, nuclei on the ventricular surface are driven away from this surface by a collective displacement effect generated by other nuclei migrating toward the ventricular surface.
Computational results, based on our values of elastic moduli, suggest that the TM facilitates the directional cooperativity of sensory cells in the cochlea, and that mechanical properties of the TM are tuned to guarantee that the magnitude of sound-induced tip-link stretching remains similar along the length of the cochlea.
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