In the interim, we assume a rapid rate of CD4 decline after ART interruption based on other trials [ 36– 38], with an associated increased risk of OIs.
Even if DTC evidence was available, ITC evidence based on other trials may be useful because of differences in patient characteristics and study characteristics such as length of follow-up [ 11].
Based on one other trial (664 participants), there is no clear evidence that sending questionnaires early increased or decreased response (RR=1.10; 95% CI 0.96 to 1.26; p=0.1.26
If these were not available, we intended to recalculate the relative risks for sensitivity analysis using a design effect inflation of SE 19 by the pooled estimate based on other cluster randomised trials.
TAME is now in its planning stages and will open the door to more trials based on other promising drugs.
Because fluroxypyr has no current recommendation for use with radiata pine or for control of broom (Young 2015), application rates used in this trial were based on other uses of this herbicide.
A retention rate of 80% over the twelve month follow-up was estimated based on other local experience with longitudinal, community-based trials, to ensure 24 families completed the study [ 44].
However, opinions based on other evidence, such as Walter Isaacson's bestselling biography about Jobs, should be kept out of trial, they argued.
Those differences are based on other factors.
This standard was based on one trial for all exercises.
