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Using data from the International Schizophrenia Consortium with men defined as the discovery sample and women as the target sample, the authors showed that a score based on all SNPs with P < 0.5 was most strongly and significantly correlated with schizophrenia in the target sample compared to the scores based on other thresholds.
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The data were further analyzed by using a PPV threshold of ≥13%, based on other studies [ 22- 26], and the mean threshold of 12.5% reported in a systematic review [ 27].
This threshold is based on other published genome-scale RNAi analyses and chosen to include expected essential genes (PLK1, KIF11, ARPC3) [ 4, 27- 29].
The effects of MWCNTs with different properties on mechanical reinforcement as well as on the electrical percolation threshold of composites based on other types of polymers, such as high density polyethylene and polyamide, have also been shown in other works [22,31,32].
Those differences are based on other factors.
Individual trials containing eye movements and other artifacts (on average 15 ± 7%) were removed before averaging, based on individually tailored artifact rejection thresholds and visual inspection.
Similarly, the proportion of the potential SCZ drugs found in other mental disorders, according to clinical trials using the threshold of Score_S ≥ 3 was higher than those based on the other two thresholds (28.0% vs. 7.5% and 0.8%).
PTMs derived from (GCtimes GC) biomarker ROIs corresponding to 34 injections (refer Table S1 for details on origin) were compared pairwise against each other based on the threshold-based cross-PTM score.
The other segmentation methods are based on fixed thresholds delineating all voxels with an activity concentration of at least 40% (T40), 50% (T50), or 60% (T60) of the measured maximum activity, respectively.
The mathematical methods behind the algorithm are simple but contrast with other proposed methods which are based on calculating thresholds and control charts.
Simple matrix algebra makes the method an efficient alternative to other techniques based on distance threshold that generally require a priori information on the explored environment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com