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Based on orthologous annotations (see OrthoMCL clustering below) these enzyme annotations were transferred to the E. falciformis proteome.
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Gene ontology annotation based on orthologous relationships with Drosophila melanogaster genes placed the honeybee differentially expressed genes (DEGs) into distinct categories of Biological Process and Molecular Function, depending on developmental time, revealing the functional elements required for adult exoskeleton formation.
For chicken Ensembl or Genscan gene predictions, GO annotations were based on orthologous human peptide sequences.
Automatic assignment of functions based on orthologous gene relationships is one of the key processes in electronic annotation of databases [ 2].
Genome annotation is commonly done by orthologous inference, the transfer of annotation across genomes based on orthologous relationships between genes in different genomes.
This gave a functional annotation of sequences based on orthologous proteins [ 18].
Existing automated solutions include the prediction of phenotypes based on orthologous genes (Groth et al., 2007; McGary et al., 2010) as well as functional annotations of genes (King et al., 2003).
For annotation by comparative mapping with the human genome, primers were designed based on orthologous human and/or porcine sequences.
The time of divergence (with error range shown in parentheses) of BMR and 12 other mammals based on orthologous proteins.
In these cases, we do not have any validation information based on orthologous sequences.
Another reason for the small number of annotated genes is because most of the current annotations are based on A. thaliana, B. rapa and P. trichocarpa and we already subtracted the sequences orthologous to them.
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