In spite of these limitations, further preclinical evaluation of botanicals and herbs and their constituent compounds using validated scientific methods is warranted based on numerous anecdotal observations of clinical benefit in patients with epilepsy and published reports showing mechanisms of action relevant to epilepsy or anticonvulsant effects in animal models of epilepsy.
By using this method, an exact calibration curve based on numerous cluster masses that each differed by 82 Da (NaC2H3O2) was obtained.
Unlike the seismic design codes in which the factors like R, I, C d, etc. are a necessity for design, PBPD method does not require such factors that are based on numerous engineering judgments which are axiomatically debatable.
The model is based on numerous simplifying assumptions on the geometry and mechanics.
This finding was predicted based on numerous studies in rats (Vandenberg et al. 2007).
Based on this assumption, numerous methods for motif-based TF binding site and TF target gene prediction have been developed that utilize sets of orthologous sequences from multiple species.
The clearing and staining procedures are largely based on the numerous clearing methods available (Johansen, 1940; Foster, 1949, 1950; Morley, 1949; Fuchs, 1963; Lersten, 1967; Shobe and Lersten, 1967; Payne, 1969).
The main message was as follows: "Even when practice is based on the methods of evidence-based medicine, numerous grey areas and uncertain indications for treatment remain.
