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Selection of this brain region was based on neuropathological changes detected in autism [ 24].
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We designed our approach based on neuropathological characteristics of AD to investigate apoE levels in relation to the APOE genotype and AD-related neurofibrillary changes, and amyloid deposits.
HD subjects had no evidence of other neurological disease based on neuropathological examination.
All biopsies were from grade IV GBMs (WHO grading system) based on neuropathological diagnosis.
Neuropathological data are themselves cross-sectional (that is, can only be collected once); it is difficult, therefore, to determine sequence and causality based on neuropathological findings.
This double mutation is probably pathogenic based on neuropathological findings, in silico prediction analysis and exome sequencing.
All biopsies were primary glioblastomas based on neuropathological diagnosis and genomic analysis by array comparative genomic hybridization (see Supplementary Table 1 for clinical details and genomic profiles).
Nevertheless, the finding that poly GA) levels in cerebellum associated with pTDP-43 pathology in the frontal cortex adds strength to the notion that, like poly(GP), cerebellar poly GA) differs based on neuropathological subgroup.
One of the few studies shows that, in line with the theory based on the neuropathological changes, more specifically white matter lesions, people with possible VaD may experience an increase in the experience of the motivational-affective aspects of pain.
We conclude that the neuropathological findings in PCH-2 are sufficiently specific to enable an unequivocal diagnosis based on neuropathology.
Prediction of global system changes based on local changes.
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