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It is possible that function-based normalization based on neural activity evoked by more controlled experiments could be more effective for a specific functional region.
In summary, our results indicate that functional registration based on neural activity while watching a movie is a further refinement beyond anatomical registration, and cross-validates both to the other half of the movie and to another experiment entirely.
Furthermore, analysis of neural connectivity in this study was based on neural activity recorded during NoGo trials, i.e. trials in which actions (and thus cortico-striatal connectivity) should not be facilitated.
Functional alignment based on neural activity evoked by watching a movie clearly enhanced the GLM group statistics in the unrelated experiment on face and object perception, indicating that our method may be of general utility for functional neuroimaging research on a wide range of sensory, perceptual, and cognitive functions.
In order to examine whether functional registration based on neural activity evoked by watching a movie increased the alignment of category-specific cortical topographies, we also performed a GLM analysis on the contrast between responses to faces and to nonface objects across subjects.
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