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Hub genes were firstly defined based on network topological features using Cytoscape version 3.2.1 [ 30].
We proposed relevant miRNA-mRNA target relationships in an AD based on network topological priorities and miRNA mediated mechanism in AD pathology.
With the integration of network topology and gene expression, the same group of researchers proposes a new method called PeC [ 23]which increases the predictability of essential proteins in comparison with those centrality measures only based on network topological features.
The experimental results show that the integration of network topology and gene expression increased the predictability of essential proteins in comparison with those centrality measures only based on network topological features.
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In this paper, a topological analysis based on network theory is presented, which aims at identifying key elements in the structure of interrelated risks potentially affecting a large engineering project.
Among the few works that have investigated the evolution of TCA cycle in eukaryotes, a recent paper has shown evolutionary similarity between mitochondria from S. cerevisiae and Rickettsia prowazekii in topological analyses based on network alignment and motif identification [ 47].
Network topological properties could efficiently explain regulatory rewiring based on network structure.
Together, this indicates that time windows for axon growth influence the topological and spatial properties of neuronal networks opening up the possibility to a posteriori estimate developmental mechanisms based on network properties of a developed network.
We also design an improved random forest classifier based on these network topological features, and a cross-validation test confirms that our method performs better than previous similar studies.
Figure 1a illustrates the clustering based on the network topological proximity while Figure 1b shows the clustering based on similar expression patterns.
Here two categories of objective functions are built, one is based on the topological characteristics of the network and the other captures gene ontological similarity of proteins.
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