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To assess the reliability of treatment recommendations based on network meta-analysis (NMA).
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Based on a network meta-analysis involving indirect comparison of trial findings, the following observations were made for DMARD-IR patients.
NICE [ 8] performed an economic evaluation based on a network meta-analysis in which the probability of discontinuation due to serious adverse events and the probability of response in patients without those adverse events were estimated.
The primary source of clinical input data was the RE-LY trial, 12 13 and an adaptation of a published mixed treatment comparison based on a network meta-analysis to synthesise efficacy and safety data of treatments frequently used in prevention of stroke and SE in patients with AF.
Based on a network meta-analysis involving indirect comparison of trial findings, the following can be concluded for DMARD-IR patients: In monotherapy, tocilizumab was associated with greater improvements in pain and self-reported disease activity (PGA) than aTNF, and is at least as efficacious regarding functional ability (HAQ-DI).
There is probably no difference of clinical efficacy between IFX and ADA, although this statement is based on indirect evidence and on a network meta-analysis from one research group.
Figure 2 shows the network of eligible statin and dose comparisons for the base case network meta-analysis.
We performed a network meta-analysis based on 26 studies.
We therefore performed a network meta-analysis based on a systematic review of completed randomised trials comparing different interventions for patients with localised prostate cancer.
A network meta-analysis based on a systematic review of the literature was performed to estimate the relative efficacy of abatacept compared with other relevant biologic DMARDs in the treatment of RA patients with insufficient response to MTX.
A fixed-effect model was used for network meta-analysis based on the star-shaped evidence network, which is typically analyzed with such an approach, and after having confirmed that model fit was not different from a random-effect and a fixed-effect model computing values for deviance information criterion (DIC).
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