Such 'antagonistic' correlations may be based on negative genetic linkage or pleiotropic effects (Baatz and Wagner 1997).
Based on this negative correlation, the current study revealed the whole-brain connectivity modular architecture for two contrasting temperament groups.
This implies that the high enzyme activity of GBSS1 was reflected to low palatability based on the negative correlation between GBSS1 activity and palatability (Table 4).
Another limitation is that the identification of modules is based on a negative correlation between miRNAs and mRNAs.
This downregulation was not in accordance with the expected transcriptional response based on the negative correlation between Treml1, D3ZDX3_Rat, Treml2, and each trans-eQTL gene expression.
The mean maternal and paternal recombination rates were estimated to be 1.28 and 0.76 centimorgans per megabase respectively, consistent with expectation based on the negative correlation between recombination intensity and genome size observed in previous studies [ 31].
Our results are further sustained by the fact that highly expressed genes may be under greater selective constraints than lowly expressed genes, based on the negative correlation between d N, ω, expression level and expression breadth in both P. glauca and P. abies (supplementary tables S1 and S2, Supplementary Material online).
In the present study, based on the negative correlation between TF/FVII and LC3 expression in 70 HCC patients, we investigated the role of TF/FVII/PAR2-mediated signaling in the regulation of autophagy and the involvement of mTOR activity in human HCC by in vitro and in vivo evidences.
The results of this comparative analysis showed that 61 53 % genes predicted to be miR-155 and miR-802 targets based on our negative correlations showed downregulation in trisomy 21 cells, and more interestingly from the same miRNA prediction lists 59 58 % presented a normalization of its expression upon extra HSA21 silencing (Additional file 2: Figure S3B).
For each miRNA, the expected outcomes are shown in the left box of Table3 as either positive or negative correlations based on the high correlation pairs in Table1, or no change (blank space) because the measured mRNA is not highly correlated with endogenous fluctuations in the test miRNA.
