Gating was implemented based on negative control staining profiles.
The present work was totally based on negative data.
Thus in the Pap-smear triage the number of further referrals for colposcopies (HPV-positive and abnormal cytology) was estimated based on the colposcopy rate of women under 40 years who were invited for triage Pap-smear in the studies, although the referral rate might be age dependent in reality.
While professional clinical societies and cancer prevention experts will need to establish the thresholds of risk and the appropriate clinical responses, current clinical algorithms based on cytology and colposcopy, such as those recommended by the American Society for Colposcopy and Cervical Pathology (9, 32), can provide some guidance for risk-based algorithms (31).
The prevalence of CIN was evaluated by a composite diagnosis based on colposcopy and histopathology results.
Formulating a follow-up management plan based on colposcopy for an abnormal smear significantly associated with glandular abnormality, is clearly unreliable.
Regular audits of the provincial registry for CIN2+ lesions that were not based on a FOCAL trial colposcopy referral identified one adenocarcinoma and one endometrial cancer, both diagnosed ~20 months after the baseline screens (HC2, COBAS and LA were negative for both cases).
The majority of published studies, regarding intelligent systems for cervical cancer support, are concerned about computer aided diagnosis systems based on either cytology or colposcopy image analysis [ 28– 31].
The cost of treatment of high-grade SIL was based on cost of initial colposcopy and biopsy, LEEP, and subsequent reexamination and Pap tests.
The cost of treatment for SIL or cervical cancer was based on cost of initial colposcopy and biopsy, therapy, and subsequent follow-up.
