Sentence examples for based on mutational patterns from inspiring English sources

Putative functional effects of mutations are based on mutational patterns.

PDAC can be classified based on mutational subtypes and 18gene alterations.

Unbiased clustering, based on mutational context, revealed clinically relevant subgroups regardless of the tumors' tissue of origin, highlighting similarities in evolutionary dynamics leading to hypermutation.

Here, we review data that show substantial genetic similarities across major anatomic cancer types and that propose novel tumor classifications based on mutational profiling.

Hierarchical analysis revealed clustering of the cell lines based on mutational status; the EGFR-mutant cells lines clearly segregated from the -wild-type cell lines (Fig. 1).

These studies suggested several hypotheses based on mutational biases or selective constraints.

No differences in the involvement of oncogenic pathways were noted between the two sites, based on mutational profiles.

The scoring system is based on possible mutational patterns of the sequences.

The design goal for DDiMAP is to evaluate tumor heterogeneity in follicular lymphoma, a cancer of B-lymphocytes that is well characterized with regard to ongoing AID-mediated somatic hypermutation of IGH, with the long-term objective of classifying FL based on their mutational patterns.

Vogelstein et al. recently described the so-called '20/20 rule' to detect tumor suppressor genes and oncogenes based on their mutational pattern across tumor samples (Vogelstein et al., 2013).

However, the influence of specific mutations on mutational patterns in the genome is usually not well characterized.