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There was no difference in response to chemotherapy based on mutation status (35 37%).
Survival from stage IV melanoma diagnosis was not significantly different based on mutation status.
One problem related to patient selection based on mutation status is the method of detecting EGFR mutations.
The pathology characteristics based on mutation status are presented in Table 3. Table 4 shows a more detailed breakdown of grade 3 tumours.
DFA CV1 values were significantly different between cells based on mutation status for all comparisons (Wilcoxon P-values 0.00005 0.01, Table 1, Figure 2).
Reasons for lack of a significant objective response in this trial could include heterogenous tumour types, lack of selection based on mutation status (e.g., PI3K or PTEN mutation) or inability to achieve sustained target inhibition with the current schedule.
Similar(53)
There was no difference in residual tumor status or in response to chemoradiation as assessed by tumor downstaging, based on mutations status.
In addition, Kaplan-Meier curves limited to the patients who received targeted therapy based solely on mutation status may be constructed for exploratory and descriptive purposes.
Table 2 shows the uni- and multivariate analyses of AKT phosphorylation based on ARID1A mutation status, BAF250a IHC expression, PIK3CA mutation status, and PTEN levels by RPPA.
To probe the association between Caspase-2 expression levels and p53 mutation status, lung adenocarcinomas (459 tumors with mutation and gene expression data) were stratified based on p53 mutation status.
Recent analyses (Bell et al, 2005) of phase II and III trials for EGFR-TKI, in which patients were not selected based on their mutation status, have suggested that EGFR mutations are correlated with response to therapy but are not correlated with overall survival (OS).
More suggestions(15)
based on mutation type
based on secretor status
based on mutation information
based on mutation detection
based on network status
based on mutation bias
based on health status
based on draft status
based on activation status
based on smoking status
based on mutation testing
based on energy status
based on mutation rate
based on patient status
based on mutation analysis
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