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Based on mutation rate, number of rows is selected randomly and for each selected row, a new route generates using of same process in initiating the population.
Their analyses (based on mutation rate, inbreeding rate, linkage disequilibrium levels, etc).
Divergence times for the 12 Drosophila species are taken from Table 3 in Obbard et al. (2012) (estimates based on mutation rate); for D. affinis and D. miranda from Gao et al. (2007) ; for D. lowei from Beckenbach et al. (1993).
Based on mutation rate data from D. melanogaster, scaled to the slightly larger D. serrata genome size [0.215 pg (Gregory and Johnston 2008)], we predicted an average per MA line accumulation of 34 mutations, composed of 19.6 [confidence interval: 16.8; 22.8] single-nucleotide mutations (Keightley et al. 2009) and 14.8 [C.I.: 3.4; 52.2] indels and complex mutations (Haag-Liautard et al. 2007).
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Wayne and his colleagues calculate, based on mutation rates and observed genetic differences in their samples, that dog domestication began between 18,800 and 32,100 years ago, and that canines were well entrenched with people between 15,000 and 20,000 years ago, before humans farmed.
Based on mutation rates of 2 and 4% per site per Ma [25] and 607 bp sequence length, u is 24.3 48.6 Ma; t in generations was converted to time in years (T) using generation time estimates of 0.5 1 year [36].
We present a probabilistic approach based on mutation rates that can be used to identify the most likely source of infection.
In the latter step, the statistical confirming procedure, the two lists of possible OGs and TSGs undergo four tests to assess whether the mutational pattern in each gene shows statistically defined evidence of positive selection based on the mutation rate and the number of non-silent mutations, calculating their statistical probability of being true driver mutations.
Empirically, it will be up to an individual laboratory to determine how many offspring they can efficiently screen and how they will prioritize mutant mice for subsequent analysis based on the mutation rate of their transgenic lines and available resources.
For the nematode C. elegans, there are direct estimates of the per-generation nuclear and mtDNA mutation rates based on mutation-accumulation line systems [ 5, 6].
Based on the mutation rate in the mitochondrial gene, the researchers estimate that the animals became isolated on Borneo some 300,000 years ago, when the island was still part of the Asian mainland.
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