Sentence examples for based on mutagenesis studies from inspiring English sources
Based on mutagenesis studies, Arg488 and Arg492 in CDC25B have been shown to be required for CDK2 substrate recruitment through ionic interactions with Asp206.
Each of these proteins was shown based on mutagenesis studies to have a function in the regulation of seedling growth in response to light.
The importance of the DFGWG motif, which is highly but not absolutely conserved, for enzyme activity was first shown in a Salvia malonyltransferase [ 5] and a Rauvolfia vinorine synthase [ 6] based on mutagenesis studies of the Asp residue.
Based on mutagenesis studies, the same authors discussed the significance of the conserved Pro-41 residue (residue number correspondent to primary structure of the Cry8Ka toxins - Figure 7) in maintaining the stability of Cry8Ea1.
However, as the central core of the α/β hydrolase superfamily members is highly conserved, the model offered first insights into the MAGL active site with the catalytic triad (S122-D239-H269), previously identified based on mutagenesis studies (Karlsson et al. 1997).
The original evidence that homologues of CodA from E. coli may have promiscuous activity for the deamination of 5-methylcytosine is based on mutagenesis studies that produced a more efficient 5-fluorocytosine deaminase, with the ultimate goal of transfecting cancer cells with this enzyme.
A systematic study of Xcc TBDRs, based on mutagenesis, expression analyses and transport assays identified one Xcc TBDR involved in the transport of sucrose, a major plant sugar.
Until recently, most methodologies used to study the molecular mechanism involved in plant embryogenesis were based on mutagenesis approaches, and were mainly conducted in a few plant species, namely, Arabidopsis, rice and maize.
Also, based on mutagenesis experiments on other polar pocket residues,31,32 the R150S variation is likely to be a loss-of-function variant.
The intracellular concentration of SAM has been increased by a strain improvement based on mutagenesis.
In the present study, we report more complete assignments for the connection and RH domain resonances based on extensive mutagenesis studies.
