Sentence examples for based on murine knockout from inspiring English sources
These targets have been previously identified, based on murine knockout models or significant associations between biomarker data and adverse pregnancy effects, as critical to proper embryonic blood vessel formation or maternal fetal placental circulation.
Aside from regions of interest defined by chromosome deletions and translocations, the other traditional strategy to identify candidate genes in POI is to study genes whose product is known and plays a role in human folliculogenesis or shows an organ-specific effect based on murine knockout models (candidate genes).
Replication-defective vectors based on murine oncoretroviruses were the first gene transfer vectors to be used in successful gene therapies.
We have previously used cVLPs based on murine polyomavirus and murine pneumotropic virus as vaccines against Her2/neu expressing tumours.
Early mAbs were based on murine or chimeric antibodies that were modified to target human antigens.
In the current investigation, we have refined our previous model based on murine CEACAM1 crystal structure (Tan et al., 2002).
In this respect, great knowledge can be obtained from tendon developmental studies based on gene knockout and reporter mouse strains (Dex et al. 2016).
However, further studies based on gene knockout techniques are required to properly identify and explore their functions.
Using a transgenic ESC reporter line based on a murine Atoh1 enhancer, we show that differentiated hair cell-like cells express multiple hair cell markers simultaneously.
Based on a murine airway infection model, inactivation of mutS renders P. aeruginosa less virulent [28], [43].
