Accurate analysis of the repertoire of such elements in a given population based on multiple genome profiling approaches could reveal significant aspects of ongoing evolution (and transmission) and the available magnitude of genetic diversity among the strains could thus be unraveled.
In order to investigate the organism-specific influence of each individual amino acid on substantial ribosome stalling, we performed a large scale analysis based on multiple ribosome profiling datasets of 9 organisms including eukaryotes (H.sapiens, C.elegans, S.cerevisiae, S.pombe, A.thaliana, P.falciparum, D.melanogaster, M.musculus) and bacteria (C.crescentus).
Another study by Glaysher and colleagues used an ATP-TCA to assess chemosensitivity in 49 surgically-resected NSCLC tumor samples and fit multiple-regression models to explain sensitivity based on multiple gene expression profiles.
A key idea underlying chromatin state analysis is to computationally identify the number and composition of chromatin states in the genome based on multiple genome-wide profiles of histone modifications and to annotate the genome with these chromatin states.
These profiles were based on multiple sequence alignments and profile-hidden Markov models from the 'Pfam' protein family database [13].
Based on multiple sequence alignment and profile alignment of WT human, cow, goat and mouse sequences with that of the template, all the available mutations were mapped to the structural models of β-mannosidase in the context of the active site of the enzyme.
The novel tool registers peaks for non-targeted metabolite profiling based on multiple criteria.
A positive result would validate the query profile and furthermore lead to a more robust core response profile based on multiple experiments.
Protein interaction network used in this study is a prediction output based on multiple parameters which includes phylogenetic profile, gene distance and operonic frequency [ 18].
However, to delineate the main differences between the molecular signatures of PCM and MM samples, they have focused only on the differential expression profiles based on multiple hypothesis testing such as Wilcoxon test [ 19], Student's t-test [ 17] or significance analysis of microarrays (SAM) [ 9, 15, 18].
