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In this study, we proposed a pathway-based clustering approach to unveil disease heterogeneities based on multiple pathways.
The agreement between the clustering results based on multiple pathways and the original partitions was also evaluated by calculating the ARI.
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Resulting annotations are used by the PathoLogic algorithm implemented in Pathway Tools to predict metabolic pathways based on multiple criteria including proportion of pathways found, pathway specific enzymatic reactions, and purported taxon-specific pathway distributions.
However, the meta-analysis for pathway analysis based on multiple microarray datasets has not been systematically pursued.
Simulations on increasing proportions of the total component genome length (Gm) showed that the performance of pathway recovery based on multiple metrics (F-measure, Matthews Correlation Coefficient, etc).
This analysis was carried out by detecting known metalloproteins, metal transporters and cofactor biosynthesis pathways, and where possible, calls were based on multiple evidences.
In this study, we propose 89 new Wnt/β-catenin pathway target genes predicted in silico by using a method based on multiple Classification and Regression Tree (CART) analysis.
"The confirmation is based on multiple intelligence sources".
"However, presidential support is based on multiple influences -- including partisanship.
This assessment is based on multiple lines of evidence.
Nantes's original industrial prowess was based on multiple sectors.
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