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Techniques like adhesion-based separation and FACS also allow for the identification of cells based on multiple marker expressions, such as distinguishing mature endothelial cells from endothelial progenitor cells based on KDR+ expression on all endothelial cells and expression of CD34+ only on stem cell populations.
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Historically, congruence has also played a decisive role in critical phylogenetic analyses based on multiple markers.
Therefore, an approach based on multiple markers could offer an alternative to monitor the course of this disease in patients.
However, this procedure can be easily modified to apply to a situation with haplotypes based on multiple markers.
To avoid this issue, we focused on physical to genetic distance ratios based on multiple markers mapped from the same contigs (Table S2).
It has been shown that a model including both haplotypes based on multiple markers and relationships between them, yields ~25 to 500 times as many effects that need to be estimated as a model based on single marker alleles [ 3].
This method can not be applied directly for haplotypes based on multiple markers, because discrete haplotypes can not be directly constructed based on predicted continuous gene contents of SNP-markers for ungenotyped animals.
Yet, it is worth debating whether the particular solution of a "banyan tree" based on multiple markers is the only valuable result of evolutionary analyses [ 12, 16, 21, 40].
Pharmacologic glucose-lowering interventions might be appropriate for pre-diabetic individuals with both IFG and IGT or for those with particularly high-risk ethnicity, those with IFG plus metabolic syndrome, or, along the lines described by Stern, those satisfying a risk score based on multiple markers.
They also show a close relationship to P. pyrifolia based on multiple molecular marker data and thus were treated as P. pyrifolia White Pear Group [ 11, 14, 17].
Cell sorting based on multiple surface markers such as CD25, CD127, CD62L and CD27 yields a high purity of FoxP3pos Treg.
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