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Multivariable prognostic research enables the development of tools which give predictions based on multiple important factors; these are variously called prognostic models, prediction models, prediction rules or risk scores [ 1].
However, learnings from past clinical failures of vaccine candidates and a better understanding of the immunopathology of S. aureus colonization and infection have aided in the design of new vaccine candidates based on multiple important bacterial pathogenesis mechanisms.
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Existing statistical approaches used in this area, primarily based on multiple regression, have important limitations: Formal tests for the difference across windows cannot be performed, missing data cannot be easily incorporated, and variation in the timing of exposure cannot be easily accommodated.
In another study, robust optimization based on multiple geological realizations is important to capture the geological uncertainty of this process (Dang et al. 2015d).
However, detailed homology analysis and structural modeling based on multiple complete sequences reveals important structural features (see Additional file 1).
One important issue of channel estimation based on multiple pilot OFDM symbols is how to distribute the pilots along the time axis.
In order to get a true evolutionary relationship it is important to derive a single tree based on multiple distance estimates encompassing different molecular events.
A systematic computational analysis based on multiple ChIP-Seq and gene expression datasets suggests that FOXA1 is a potentially important negative regulator in the EMT of lung adenocarcinoma.
Another important future direction to extend MixClone is to implement joint analysis based on multiple samples, which is supported by PyClone and PhyloSub [ 5, 7].
In fact, there are strong evidence-based arguments supporting the rationality of capital shares over many decades based on multiple studies, multiple researchers, multiple methods, and the examination of multiple forms of capital shares.
It is important to note that selection of specific transgenic events for incorporation in breeding programs is based on multiple considerations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com