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Other approaches involve the use of clustering algorithms to classify patients into categories based on multiple clinical attributes.
In doing so, we trialled an alternative and entirely feasible methodology for creating a gold standard set based on multiple clinical practice guidelines rather than traditional hand searching or systematic reviews.
We utilized a stepwise regression method, called LASSO, to generate a predicative model of proliferative nephritis based on multiple clinical and experimental variables (Fig. 5a and Figure S2 in Additional file 1).
This may reflect a common belief that meta-analyses should be based on multiple clinical trials, which are very common in cancer studies and less common in other fields.
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Diagnosis of chronic pain due to disk degeneration is complex and based on multiple criteria, including clinical findings, as well as on radiographic and MRI and/or invasive discography.
The evidence for the benefit is based on multiple, well-designed randomized clinical trials.
To identify a PJI, we developed an algorithm based on multiple data sources from microbiology, clinical findings described in the medical record, antibiotic treatment prior to the revision, and preoperative CRP levels < 10 mg/L.
Nevertheless, since the cause of LOAD is multifactorial [ 36], it is improbable that single (protein) markers can accurately define this complex pathology; an algorithm based on multiple biomarkers should deliver a more accurate clinical diagnosis [ 35].
The assessment was extensive, lasting approximately 20 25 hours in total for each individual and was based on multiple sources of information: a semi-structured clinical interview based on the Diagnostic and Statistical Manual of Mental disorders- Fourth Edition [ 11] was conducted in all cases.
The analysis for the internal motion can be done based on multiple 4DCTs that were obtained as part of the clinical protocol and are currently under investigation.
25 This suggests that the choice of variables to include in clinical prediction models preferably should be based on multiple cohorts at different times and/or different settings.
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