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"Our systematic review is based on more trials and more participants, and hence is more powerful".
Compared with that review, our analysis has the disadvantage of using the surrogate outcome of glucose lowering, albeit a well-established surrogate on which treatment guidelines are based (4, 17, 18), but it has the advantage of an estimate based on more trials.
Also, the three most recent studies [ 7, 20, 22] were more sensitive at measuring differences than the earlier studies [ 21, 24], because results were based on more trials, had a larger age range, were analyzed per year group and step sizes were smaller.
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The Bondronat summary was chosen because the data were based on more than one trial and its size is representative of most EPAR summaries between one and two pages long.
An exhaustive experimental sensitivity analysis of the close loop system performance based on more than three hundred trials in a test bench is presented.
I therefore support the conclusions that further data based on more realistic field trials is required".
I therefore support the conclusions that further data based on more realistic field trials is required". Sandra Bell of Friends of the Earth said: "Bee health is far too urgent to wait until more research has been completed – restrictions should be placed on these pesticides until bee safety can be assured". There have been previous suspensions in France, Italy, Germany and Slovenia.
He said that the results of the Fera bumblebee study suggested that the extent of the impact might not be as high as some studies had suggested - and called for "further data based on more realistic field trials is required".
These analyses, based on more than 150 000 trial participants and 15 000 major cardiovascular events, are uniquely powerful and provide precise estimates of the effects on major cardiovascular events of the most widely used regimens to lower blood pressure in patients with and without chronic kidney disease.
To the best of our knowledge, the ways in which risk of bias judgements change when they are based on more detailed reports of trials, such as those contained in clinical study reports, have not been previously investigated.
Based on more than 40 failed clinical trials in septic humans, it is clear that extrapolation of data obtained from septic (CLP) or endotoxemic rodents does not necessarily provide reliable predictions for septic humans.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com