Sentence examples for based on molecular targets from inspiring English sources
Rational drug design based on molecular targets is starting to revolutionize cancer care.
We defined the dissimilairty measure between any two drugs D i, D j ∈ D as: K CHEM ( D i, D j ) = 1 − JI ( ℬ i, ℬ j ) + CS ( ℬ i, ℬ j ) + DC ( ℬ i, ℬ j ) 3. The same measure was used to compute drug similarities based on molecular targets, obtained for 1571 drugs from the DrugBank database.
Current challenges in oncology include prediction of tumour behaviour and selection of effective therapy for individual treatment based on molecular targets.
Understanding mechanisms of xanthone action should allow for the design of combination treatment using xanthones with other therapies, based on molecular targets.
Although multiple treatment regimens are practised, including silicone gel sheeting, pressure therapy, corticosteroids, cryotherapy, 5-fluorouracil, laser therapy and radiation, none of these is optimal and effective, and therapeutics based on molecular targets have not yet gone beyond clinical trials.
Molecular approaches are also used to design pesticides based on molecular target identification using functional genomics tools.
In addition, ANT2 repression results in the growth arrest of human cells, implying that ANT2 is a candidate for cancer therapy based on molecular targeting.
Overall, such "genomically informed cancer therapies" are proving far superior over non-targeted therapies and have prompted calls for reclassification of cancers based on molecular profiles and targets instead of being based on traditional histopathology and origin and opened the door for the Precision Medicine Initiative [ 15].
With assays based on molecular techniques, the genetic targets vary, as does the method of target characterization.
Another freely available target identification tool published recently includes TB Mobile 2.0 which identifies potential targets based on molecular similarity [39].
It can also cluster compounds and use internal algorithms to help identify potential targets based on molecular similarity.
