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Our results were based on modest numbers, and these SNPs have not been studied in independent samples of brain tumor patients, making the probability of false positives high (Wacholder et al. 2004).
The data suggested that the resolution of studies based on modest numbers of markers was perhaps not sufficient to elucidate the true number of small scale genomic inversions that have taken place in genome evolution within the Rosaceae, which may have played an important role in speciation within the family.
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Taken together, association studies of DYX1C1 have generated contradictory findings based on modest association signals.
This is not surprising, as we built the networks based on a modest number of pre-selected variables closely related to the complex disease of interest.
These findings suggested that the increased TMEM106B expression in brain could be linked to FTLD-TDP pathogenesis, however, they were based on a modest number of brain samples (n = 25).
Hadlock's fetal growth curve [ 32], based on a modest number of White fetuses from the 1980s, does not appear to fit well with our study sample (U.S. cohort), because birth weight-for-gestational-age z-scores among preterm live births were not substantially below 0 at most preterm GAs, as has been observed in previous studies [ 21, 22].
But all those species were established based on only a modest numbers of fossils.
Although many of these studies are based on samples from modest numbers of patients, there is value in the systematic capture and presentation of this information alongside large-scale studies such as those presented by TCGA and ICGC.
Also overestimates may be a consequence of over-fitting a model with many risk factors based on only a modest number of cases and controls [ 28].
The studies in humans demonstrated a relatively more modest effect on inflammation based on absolute numbers of macrophages, though proportional increases in inflammatory macrophages were evident.
Some are based on the numbers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com